The kidneys are a pair of organs located towards the lower back. There is one kidney on each side of the spine, and they work 24*7 to help flush toxins from the body. The kidneys send these toxins to the bladder, which later on removes them through the urine.

Renal failure or kidney failure is when the kidneys lose their ability to filter waste substances from the blood. By this time, the GFR level in the body drops to 15% of normal. You may experience symptoms from the buildup of waste products and extra water in the body, such as heart failure, heart arrhythmia, etc.

Many conditions can interfere with the kidney's ability to filter waste substances from the blood, such as:

• toxic exposure to environmental pollutants or chemicals
• medications
• acute and chronic diseases
• dehydration
• kidney trauma or injury